I mentioned earlier exactly what LDN was and I will explain the best way I know how exactly what it is and maybe how it will help. I will be taking this information from other websites and will try to show where I found each bit of information.
When I had my last blood work, my Natural Killer Cells were on the low end of normal. Natural Killer Cells are cells that fight against cells that don't have a "banner." (1) These cells fight against cancer, viral and other cells that attack our bodies. If we don't have NK Cells, then our bodies can not fight against these other cells leaving a very weak immune system.
In the last few months, I have been reading all about an old drug that has a powerful effect on those with different diseases. I have even seen about this drug on Lyme forums. Based on past experiences with my doctor, I jump on pretty much anything he suggests to help since everything he has done for me in the past has given me progress. It does not make me any less timid to try something new and I still do research on any potential treatment plan. However, I trust my LLMD with every treatment plan he proposes.
So when my LLMD suggested Low Dose Naltrexone (LDN), I was fairly ready to try something different. However, it did take me a few weeks to really jump on board. He starts describing LDN and tell me that Naltrexone was approved by the FDA back in the 80's to help drug and alcohol addicts beat their addiction. (2) Obviously, this did not settle in my brain. Why would I want to take something that was prescribed for drug & alcohol addicts? Then he explained that in 1985, a doctor discovered that it has immune boosting properties when given in teeny tiny doses for his HIV patients. (2) Then again he noted the improvements for his cancer patients in the 90's. Then, he noticed some improvements in autoimmune disease cases. (2) This picqued my interest. He told me to go home and research it while he would get in touch with the pharmacy that would compound it for me.
Now all that information is fine and dandy, but what does it do? How does it work? Well apparently it blocks the opioid receptors in between 2 and 4am when taken at bedtime. If I'm understanding correctly, this extended time of cutting off the opoid receptors actually causes an increase in endorphins and enkephalin production (3). And in some how, I am guessing this boosts the immune system.
A normal dose of Naltrexone is 50 mg. It causes opioid receptors to be blocked continously while the Low Dose of Naltrexone is between 1mg and 10 mg. I will be taking 4.5 mg which is the standard dose for a Lyme patient from my understanding. Last night was my 3rd night of LDN. First night, I slept very little. I was fatigued and miserable on the following day. I thought to myself that I would not be able to do this. Second night, I slept better and even had some nice dreams (opposed to the nightmares I have been having). I took a nap in the afternoon and last night was the third night of LDN. It was unbelievable. I had energy today. My brain was almost clear. If it keeps up like this, my 30 day trial of LDN will be over before I know it.
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